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Chiral Intermediates

Process Economics Program Report 232

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Published March 2001

Chiral chemicals are a unique class of compounds that, although chemically identical, exist as mirror images of each other called enantiomers. Chiral compounds touch many aspects of everyday life. The chirality of a compound affects how food tastes, how drugs interact in the body, and how quickly products decompose in the environment. Major identified markets for chiral compounds include:

  • Pharmaceuticals.
  • Agricultural chemicals.
  • Food and feed additives.
  • Polymers.

Production methods for chiral compounds encompass many diverse technologies. This report reviews three major technologies for the production of chiral compounds:

  • Resolution by crystallization of diastereomers.
  • Resolution by enzymes.
  • Asymmetric synthesis by biocatalysis.
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